13 Common Medications You Should Never Mix with Alcohol

Whether the pain medication is OTC or a prescription drug, talk with a doctor before drinking alcohol. Combining alcohol with any type of pain medication can cause dangerous side effects.2

Mixing alcohol with medications for muscle pain, like Flexeril (cyclobenzaprine) and Soma (carisoprodol), can increase your risk for seizures, overdose, and cause difficulty breathing.

Medications for minor pain, like Tylenol (acetaminophen), Motrin and Advil (ibuprofen), Aleve (naproxen), and Excedrin (acetaminophen and aspirin) can result in stomach pain, bleeding, stomach ulcers, and possible heart or liver damage.2

Combining alcohol with strong pain medications for severe pain, like opioids, can cause drowsiness and dizziness, difficulty breathing, memory problems, and put you at an increased risk for an overdose.

Do not drink alcohol if you are taking any strong pain medications, such as the following:2

  • Percocet (oxycodone)
  • Vicodin (hydrocodone)
  • Demerol (meperidine)
  • Darvocet (propoxyphene)
  • Fiorinal (butalbital with codeine)

7. Heartburn and Nausea Medications

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